Propuesta de mejora en el área de producción para disminuir costos operativos en la línea de producción de libros en la empresa Grupo Matisse S.A.C

El presente trabajo tiene como objetivo principal el desarrollo de una propuesta de mejora para el área de producción y lograr disminuir costos operativos en la línea de producción de libros en la empresa Grupo Matisse S.A.C. En primer lugar, se realizó un diagnóstico general de la situación actual de la empresa en estudio para el área de producción de libros, siendo seleccionada por el hecho de que posee mayor demanda y también problemas rivalizando los altos costos operativos. Luego de identificar los problemas, se realizó una matriz de priorización y junto a un diagrama de Pareto, se logró visualizar de una mejor manera las principales causas-raíz de los problemas presentados dentro de la empresa, se procedió a calcular el impacto económico que influyen en la empresa. Así mismo, se desarrolla la propuesta de mejora comenzando con la explicación a detalle del proceso productivo de la línea de libros como son: DOP, Tiempo estándar, Balance de Línea, VSM, Formatos de Producción, MRP, MOF. Además, se inició un plan de capacitación, lineamientos, plan de mantenimiento preventivo y por último se diseñó un layout. Posteriormente se realiza un análisis económico – financiero para constatar que el estudio realizado es viable para la empresa, puesto que se obtuvo un VAN de S/. S/325,862.45 , TIR de 99.31%, B/C de 1.3 y PRI de 1.4 años; cual concluye que esta propuesta de mejora es factible y a la vez rentable para la empresa Grupo Matisse S.A.C.The principal objective of this work is the development of a proposal for the improvement of the production area and to achieve a reduction in operating costs in the book production line at Matisse Group S.A.C. Firstly, a general diagnosis of the current situation of the company under study was made for the book production area, being selected for the fact that it has higher demand and also problems competing with high operating costs. After identifying the problems, a prioritization matrix was made and together with a Pareto diagram, the main root causes of the problems presented within the company were better visualized, and the economic impact on the company was calculated. Likewise, the proposal for improvement was developed, starting with a detailed explanation of the production process of the line of books, such as DOP, Standard Time, Line Balance, VSM, Production Formats, MRP, MOF. In addition, a training plan, guidelines, preventive maintenance plan and finally a layout was designed. Afterwards, an economic-financial analysis was performed to confirm that the study was feasible for the company, since a VAN of S/. S/325,862.45, TIR of 99.31%, B/C of 1.3 and PRI of 1.4 years was obtained; which concluded that this proposal for improvement is feasible and at the same time profitable for the company Matisse Group S.A.C

Actas de SABI2020

Los temas salientes incluyen un marcapasos pulmonar que promete complementar y eventualmente sustituir la conocida ventilación mecánica por presión positiva (intubación), el análisis de la marchaespontánea sin costosos equipamientos, las imágenes infrarrojas y la predicción de la salud cardiovascular en temprana edad por medio de la biomecánica arterial

Análisis de la gestión del patrocinio deportivo en el sector privado peruano: estudio del caso Herbalife Perú

La presente investigación tiene como objetivo analizar la gestión del patrocinio deportivo de una empresa con experiencia en esta herramienta de marketing en el contexto peruano. Se desarrolla en primera instancia un marco analítico basado en dos fuentes. En primer lugar, se encuentran los principales autores de la literatura existente sobre la gestión del patrocinio deportivo, de los cuales se extrajeron las cuatro amplias fases en esta gestión: Planeamiento, Selección, Activación y Medición. En segundo lugar, debido a que la teoría no proporcionaba suficiente especificidad, se toma en cuenta las opiniones de destacados expertos locales en la materia, los cuales complementaron lo hallado en la literatura. El marco analítico contribuye a la identificación de las fases más representativas y las prácticas incluidas en la gestión del patrocinio deportivo, para posteriormente realizar un análisis de la actual gestión de esta herramienta de marketing en la empresa caso de estudio. Este marco proporciona una perspectiva integral de la gestión del patrocinio deportivo, permitiendo reconocer las fortalezas y debilidades existentes de lo que hace realmente una empresa reconocida en el ámbito de patrocinios deportivos a nivel local a partir del análisis realizado. Se valida que la gran mayoría de las prácticas llevadas a cabo por dicha empresa están consideradas en el marco analítico. Sin embargo, se pudieron identificar oportunidades de mejora principalmente en las fases de Planeamiento, referido a la distribución del presupuesto del patrocinio deportivo, Activación, referido a las acciones del patrocinio de cara al público objetivo, y Medición, referido al monitoreo de los medios digitales. El aporte que esta investigación brinda a las ciencias de la gestión gira en torno a una herramienta de marketing que aún se encuentra en una etapa incipiente en el mercado peruano y no es considerada en el mix de comunicaciones de muchas empresas locales, a diferencia de otros mercados internacionales. Por tanto, surge la necesidad de generar conocimiento a través de la construcción de un marco analítico que resalte las ventajas y proporcione buenas prácticas de la gestión del patrocinio deportivo. A partir de ello, se espera que las empresas que actualmente realizan este tipo de patrocinio examinen su gestión y, del mismo modo, se incentive a las empresas que no lo realizan a diversificar sus alternativas de marketing y apostar por esta herramienta. Además, esta investigación contribuye al estado del arte acerca del patrocinio deportivo, el cual es escaso en el país.Tesi

Escuela Peruana de Buenas Prácticas

Escuela Peruana de Buenas Prácticas es un proyecto de negocio que consiste en la formación y desarrollo de habilidades blandas como empatía, comunicación verbal y no verbal, adaptación a los cambios, entre otros. Creemos que es importante poder gestionar estas técnicas para la solución de problemas, aprender a trabajar en equipo, ser líder, reducir el nivel de estrés y otros aspectos que ayuden al desarrollo de una formación que impulse al estudiante debido a que, en el Perú, el sistema educativo solo está enfocado en asignaturas básicas como matemática, comunicación, ciencias, entre otros cursos. Sin embargo, en los últimos años se ha demostrado la importancia de enseñar habilidades blandas para la toma asertiva de decisiones tanto en la vida personal como profesional. Ante esta situación, en el rubro educativo peruano existen pocos centros de preparación dedicados al desarrollo de estos cursos con una propuesta diferente. En ese sentido, este proyecto de negocio busca cubrir esta necesidad con una propuesta de valor que radica en un centro especializado que se encargará de desarrollar habilidades blandas en niños y adolescentes con docentes de larga experiencia. La Escuela Peruana de Buenas Prácticas tendrá como fuente de ingresos el pago de los padres de familia que matriculen a sus hijos, por lo cual nos dirigiremos a todos los centros educativos privados de nivel primaria y secundaria apoyándonos en campañas que nos permitan mostrar nuestra propuesta de valor.Peruvian School of Good Practices is a business project that consists of the training and development of soft skills such as empathy, verbal and non-verbal communication, adaptation to changes, among others. We believe that it is important to be able to manage these techniques to solve problems, learn to work as a team, be a leader, reduce the level of stress and other aspects that help the development of a training that encourages the student because, in Peru, the educational system is only focused on basic subjects such as mathematics, communication, science, among other courses. However, in recent years the importance of teaching soft skills for assertive decision making has been demonstrated both in personal and professional life. Faced with this situation, in the Peruvian educational sector there are few preparation centers dedicated to the development of these courses with a different proposal. In this sense, this business project seeks to cover this need with a value proposition that lies in a specialized center that will be in charge of developing soft skills in children and adolescents with long-term teachers. The Peruvian School of Good Practices will have as a source of income the payment of parents who enroll their children, for which we will go to all private primary and secondary education centers, supporting ourselves in campaigns that allow us to show our proposal of value.Trabajo de investigació

In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells

This work was supported by CaixaImpulse (CI18-00017;FuGe) to S.R-P. RT-R. is supported by a postdoctoral fellowship from the Asociación Española Contra el Cáncer (AECC). J.C.S. is supported by the Spanish Cell Therapy cooperative research network (TERCEL)(RD16/0011/0011). P.M. also acknowledges the financial support from the Obra Social La Caixa-Fundaciò Josep Carreras. P.M. is an investigator of the Spanish Cell Therapy cooperative research network (TERCEL). A.M.C. acknowledges funding fromXarxa de Bancs de Tumors de Catalunya (XBTC; sponsored by Pla Director d'Oncologia de Catalunya).Fusion oncogenes (FOs) are common in many cancer types and are powerful drivers of tumor development. Because their expression is exclusive to cancer cells and their elimination induces cell apoptosis in FO-driven cancers, FOs are attractive therapeutic targets. However, specifically targeting the resulting chimeric products is challenging. Based on CRISPR/Cas9 technology, here we devise a simple, efficient and non-patient-specific gene-editing strategy through targeting of two introns of the genes involved in the rearrangement, allowing for robust disruption of the FO specifically in cancer cells. As a proof-of-concept of its potential, we demonstrate the efficacy of intron-based targeting of transcription factors or tyrosine kinase FOs in reducing tumor burden/mortality in in vivo models. The FO targeting approach presented here might open new horizons for the selective elimination of cancer cells

Expression of TILs and Patterns of Gene Expression from Paired Samples of Malignant Pleural Mesothelioma (MPM) Patients

Gene expression; Immunotherapy; Malignant pleural mesotheliomaExpresión génica; Inmunoterapia; Mesotelioma pleural malignoExpressió gènica; Immunoteràpia; Mesotelioma pleural maligneMPM is an aggressive disease with an immunosuppressive tumor microenvironment, and interest in exploring immunotherapy in this disease has been increasing. In the first line of treatment, the combination of nivolumab and ipilimumab demonstrated an improvement in survival over chemotherapy. The presence of TILs has been recognized as a marker of antitumor immune response to chemotherapy in solid tumors. The aim of our study is to identify the effect of treatment on immune cells and the immune gene profile in MPM. We investigated the changes in expression of TILs in 10 human MPM paired tumor tissues using immunohistochemistry and gene expression analysis from paired untreated and treated samples. In this small series, we demonstrated that during the evolution of disease without any treatment there was an increase in the inflammatory component in tumor samples. After systemic treatment there was a decrease in the number of TILs. We observed that after systemic treatment or disease progression immune gene signatures were suppressed. Our integrated analysis of paired samples with immune profile and genomic changes on MPM suggested that during the evolution of the disease the immune system tends to switch, turning off with treatment.The study was partially funded by Project PREDICT-Meso (GEACC19003CED), funded by Fundación AECC

A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features

The cellular ontogeny and location of the MLL-breakpoint influence the capacity of MLL-edited CD34+ HSPCs to initiate pro-B-ALL, and recapitulate the molecular features of MLL-AF4+ infant B-ALL patients. We provide key insights into the cellular-molecular leukemogenic determinants of MLL-AF4+ infant B-ALL

Revisiting “Success” and “Failure” of Marine Protected Areas: A Conservation Scientist Perspective

Marine protected areas (MPAs) form the cornerstone of marine conservation. Identifying which factors contribute to their success or failure is crucial considering the international conservation targets for 2020 and the limited funds generally available for marine conservation. We identified common factors of success and/or failure of MPA effectiveness using peer-reviewed publications and first-hand expert knowledge for 27 case studies around the world. We found that stakeholder engagement was considered to be the most important factor affecting MPA success, and equally, its absence, was the most important factor influencing failure. Conversely, while some factors were identified as critical for success, their absence was not considered a driver of failure, and vice versa. This mismatch provided the impetus for considering these factors more critically. Bearing in mind that most MPAs have multiple objectives, including non-biological, this highlights the need for the development and adoption of standardized effectiveness metrics, besides biological considerations, to measure factors contributing to the success or failure of MPAs to reach their objectives. Considering our conclusions, we suggest the development of specific protocols for the assessment of stakeholder engagement, the role of leadership, the capacity of enforcement and compliance with MPAs objectives. Moreover, factors defining the success and failure of MPAs should be assessed not only by technical experts and the relevant authorities, but also by other stakeholder groups whose compliance is critical for the successful functioning of an MPA. These factors should be considered along with appropriate ecological, social, and economic data and then incorporated into adaptive management to improve MPA effectiveness

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Background Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods We performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results We identified 8899 CpGs in cord blood that were associated with gestational age (range 27-42 weeks), at Bonferroni significance, P <1.06 x 10(- 7), of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels. Conclusions We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.Peer reviewe

Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study

BACKGROUND: One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.OBJECTIVES: The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference.DESIGN, PATIENTS AND SETTING: This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 countries.MAIN OUTCOME MEASURES: Women and men were compared with respect to use of LTVV, defined as VT of 8 ml kg-1 or less predicted bodyweight (PBW). A VT was deemed 'default' if the set VT was a round number. A mediation analysis assessed which factors may explain the sex difference in use of LTVV during intra-operative ventilation.RESULTS: This analysis includes 9864 patients, of whom 5425 (55%) were women. A default VT was often set, both in women and men; mode VT was 500 ml. Median [IQR] VT was higher in women than in men (8.6 [7.7 to 9.6] vs. 7.6 [6.8 to 8.4] ml kg-1 PBW, P &lt; 0.001). Compared with men, women were twice as likely not to receive LTVV [68.8 vs. 36.0%; relative risk ratio 2.1 (95% CI 1.9 to 2.1), P &lt; 0.001]. In the mediation analysis, patients' height and actual body weight (ABW) explained 81 and 18% of the sex difference in use of LTVV, respectively; it was not explained by the use of a default VT.CONCLUSION: In this worldwide cohort of patients receiving intra-operative ventilation during general anaesthesia for surgery, women received a higher VT than men during intra-operative ventilation. The risk for a female not to receive LTVV during surgery was double that of males. Height and ABW were the two mediators of the sex difference in use of LTVV.TRIAL REGISTRATION: The study was registered at Clinicaltrials.gov, NCT01601223